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Which of the following is NOT one of the five classes of antibodies?

IgE

IgD

IgK

The correct answer is IgK because it is not recognized as one of the five main classes of antibodies. The five classes of antibodies—immunoglobulins—are IgG, IgA, IgM, IgE, and IgD. Each class plays a distinct role in the immune response.

IgG is the most abundant antibody in the bloodstream and extracellular fluid, providing the majority of antibody-based immunity against invading pathogens. IgA primarily exists in mucosal areas, such as the gut and respiratory tract, and is also found in saliva, tears, and breast milk, playing a crucial role in mucosal immunity. IgM is the first antibody produced in response to an infection, serving as a first-line defense by clumping pathogens together for easier elimination. IgE is involved in allergic reactions and responses to parasitic infections, particularly by activating mast cells and basophils. IgD has a role in B cell activation and is found in small amounts.

IgK, however, does not correspond to any recognized class of antibodies; instead, it may refer to the kappa light chain of antibodies, which is a part of the structure of certain immunoglobulins but not a standalone class itself. Thus, IgK is correctly identified

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IgG

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